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Publications

 

  • Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, Mahishi L, Alam S, Giger RJ, Barnes S, Morris SM Jr, Willis DE, Twiss JL, Filbin MT, Ratan RR. A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. J Neurosci. 2010 Jan 13;30(2):739-48.
  • Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29;64(2):165-72.
  • Deng K, He H, Qiu J, Lorber B, Bryson JB, Filbin MT. Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo. J Neurosci. 2009 Jul 29;29(30):9545-52.
  • Filbin MT. PirB, a second receptor for the myelin inhibitors of axonal regeneration Nogo66, MAG, and OMgp: implications for regeneration in vivo. Neuron. 2008 Dec 10;60(5):740-2. Review.
  • Spencer TK, Mellado W, Filbin MT. BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth. Mol Cell Neurosci. 2008 May;38(1):110-6.
  • Hannila SS, Filbin MT. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Exp Neurol. 2008 Feb;209(2):321-32. Epub 2007 Aug 27. Review.
  • Cao Z, Qiu J, Domeniconi M, Hou J, Bryson JB, Mellado W, Filbin MT. The inhibition site on myelin-associated glycoprotein is within Ig-domain 5 and is distinct from the sialic acid binding site. J Neurosci. 2007 Aug 22;27(34):9146-54.
  • Chaudhry N, Filbin MT. Myelin-associated inhibitory signaling and strategies to overcome inhibition. J Cereb Blood Flow Metab. 2007 Jun;27(6):1096-107. Epub 2006 Oct 11. Review.
  • Hannila SS, Siddiq MM, Filbin MT. Therapeutic approaches to promoting axonal regeneration in the adult mammalian spinal cord. Int Rev Neurobiol. 2007;77:57-105. Review.
  • Filbin MT. Recapitulate development to promote axonal regeneration: good or bad approach? Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1565-74. Review.
  • Filbin MT. How inflammation promotes regeneration. Nat Neurosci. 2006 Jun;9(6):715-7.
  • Cao Z, Gao Y, Bryson JB, Hou J, Chaudhry N, Siddiq M, Martinez J, Spencer T,  Carmel J, Hart RB, Filbin MT. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci. 2006 May 17;26(20):5565-73.
  • Domeniconi M, Zampieri N, Spencer T, Hilaire M, Mellado W, Chao MV, Filbin MT. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron. 2005 Jun 16;46(6):849-55.
  • Domeniconi M, Filbin MT. Overcoming inhibitors in myelin to promote axonal regeneration. J Neurol Sci. 2005 Jun 15;233(1-2):43-7. Epub 2005 Apr 20. Review.
  • Gao Y, Deng K, Hou J, Bryson JB, Barco A, Nikulina E, Spencer T, Mellado W, Kandel ER, Filbin MT. Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo. Neuron. 2004 Nov 18;44(4):609-21.
  • Lu P, Yang H, Jones LL, Filbin MT, Tuszynski MH. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14;24(28):6402-9.
  • Nikulina E, Tidwell JL, Dai HN, Bregman BS, Filbin MT. The phosphodiesterase  inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8786-90.
  • Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT, Bunge MB. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med. 2004 Jun;10(6):610-6.
  • Spencer T, Filbin MT. A role for cAMP in regeneration of the adult mammalian  CNS. J Anat. 2004 Jan;204(1):49-55. Review.
  • Gao Y, Nikulina E, Mellado W, Filbin MT. Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. J Neurosci. 2003 Dec 17;23(37):11770-7.
  • Filbin MT. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci. 2003 Sep;4(9):703-13. Review. Erratum in: Nat Rev Neurosci. 2003 Dec;4(12):1019.
  • Spencer T, Domeniconi M, Cao Z, Filbin MT. New roles for old proteins in adult CNS axonal regeneration. Curr Opin Neurobiol. 2003 Feb;13(1):133-9. Review.
  • Cai D, Deng K, Mellado W, Lee J, Ratan RR, Filbin MT. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron. 2002 Aug 15;35(4):711-9.
  • Domeniconi, M., Cao, Z., Spencer, T., Sivasankaran, R., Wang, K., Nikulina, E., Kimura,  N., Cai, H., Deng, K., Gao, Y., He, Z., and Filbin, M.T. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron. 2002 Jul 18;35(2):283-90.
  • Qiu J, Cai D, Dai H, McAtee M, Hoffman PN, Bregman BS, Filbin MT. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron. 2002 Jun 13;34(6):895-903.
  • Qiu J, Cai D, Filbin MT. A role for cAMP in regeneration during development and after injury. Prog Brain Res. 2002;137:381-7. Review.
  • Tang S, Qiu J, Nikulina E, Filbin MT. Soluble myelin-associated glycoprotein  released from damaged white matter inhibits axonal regeneration. Mol Cell Neurosci. 2001 Sep;18(3):259-69.
  • Cai D, Qiu J, Cao Z, McAtee M, Bregman BS, Filbin MT. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci. 2001 Jul 1;21(13):4731-9.
  • Lumsden A, Chapman S, Schubert F, Toole L, Mayford M, Hamann S, Reber PJ, Häusser M, Murthy VN, Wood JN, Liman ER, Filbin MT, Qiu J, Ashe J, Chafee M, Goodwin S, Kyriacou B, Kempermann G, Winkler J. Neurobiology. Curr Opin Neurobiol. 2001 Feb;11(1):1-9.
  • Previtali SC, Quattrini A, Fasolini M, Panzeri MC, Villa A, Filbin MT, Li W,  Chiu SY, Messing A, Wrabetz L, Feltri ML. Epitope-tagged P(0) glycoprotein causes Charcot-Marie-Tooth-like neuropathy in transgenic mice. J Cell Biol. 2000 Nov 27;151(5):1035-46.
  • Filbin MT. Axon regeneration: Vaccinating against spinal cord injury. Curr Biol. 2000 Feb 10;10(3):R100-3.
  • Qiu J, Cai D, Filbin MT. Glial inhibition of nerve regeneration in the mature mammalian CNS. Glia. 2000 Jan 15;29(2):166-74. Review.
  • Filbin MT, Zhang K, Li W, Gao Y. Characterization of the effect on adhesion of different mutations in myelin P0 protein. Ann N Y Acad Sci. 1999 Sep 14;883:160-7.
  • Filbin MT. The benefits of adding insult to injury. Neuron. 1999 May;23(1):2-4. Review.
  • De Bellard ME, Filbin MT. Myelin-associated glycoprotein, MAG, selectively binds several neuronal proteins. J Neurosci Res. 1999 Apr 15;56(2):213-8.
  • Cai D, Shen Y, De Bellard M, Tang S, Filbin MT. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron. 1999 Jan;22(1):89-101.
  • Shen YJ, DeBellard ME, Salzer JL, Roder J, Filbin MT. Myelin-associated glycoprotein in myelin and expressed by Schwann cells inhibits axonal regeneration and branching. Mol Cell Neurosci. 1998 Sep;12(1-2):79-91.
  • Tang S, Shen YJ, DeBellard ME, Mukhopadhyay G, Salzer JL, Crocker PR, Filbin  MT. Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site. J Cell Biol. 1997 Sep 22;138(6):1355-66.
  • Collins BE, Yang LJ, Mukhopadhyay G, Filbin MT, Kiso M, Hasegawa A, Schnaar RL. Sialic acid specificity of myelin-associated glycoprotein binding. J Biol Chem. 1997 Jan 10;272(2):1248-55.
  • Tang S, Woodhall RW, Shen YJ, deBellard ME, Saffell JL, Doherty P, Walsh FS,  Filbin MT. Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Mol Cell Neurosci. 1997;9(5-6):333-46.
  • DeBellard ME, Tang S, Mukhopadhyay G, Shen YJ, Filbin MT. Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein. Mol Cell Neurosci. 1996 Feb;7(2):89-101.
  • Filbin MT. The muddle with MAG. Mol Cell Neurosci. 1996;8(2-3):84-92. Review.
  • Filbin MT. Myelin-associated glycoprotein: a role in myelination and in the inhibition of axonal regeneration? Curr Opin Neurobiol. 1995 Oct;5(5):588-95. Review.
  • Mukhopadhyay G, Doherty P, Walsh FS, Crocker PR, Filbin MT. A novel role for  myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron. 1994 Sep;13(3):757-67.

Last Updated ( Tuesday, 01 June 2010 09:08 )